ROLE OF SEROLOGICAL DIAGNOSIS FOR TUBERCULOSIS

TUBERCULOSIS IS A MAJOR DISEASE OF HUMAN KIND AND IS STILL A MAJOR PROBLEM SPECIALLY FOR DEVELOPING WORLD. HOWEVER THERE IS STILL CERTAIN CONTROVERSY IN DIAGNOSIS MOSTLY DUE TO SEROLOGICAL TEST.

RECENTLY WORLD HEALTH ORGANISATION HAS CAME OUT WITH A POLICY STATEMENT ON USE OF SEROLOGICAL TEST FOR DIAGNOSIS OF TUBERCULOSIS

WHO HAS CLEARLY RECOMMENDED AGAIST THE USE OF THESE TESTS FOR DIAGNOSIS OF TUBERCULOSIS

THE DOCUMENT IN THEIR CONCLUSION MENTIONED THAT

"Commercial serological tests provide inconsistent and imprecise findings resulting in highly variable values for sensitivity and specificity. There is no evidence that existing commercial serological assays improve patient-important outcomes, and high proportions of false-positive and false-negative results adversely impact patient safety. Overall data quality was graded as very low and it is strongly recommended that these tests not be used for the diagnosis of pulmonary and extra-pulmonary TB"

FOR MORE DETAIL GO THROUGH THE ORIGINAL WHO DOCUMENT

PARASOMNIA

Parasomnias are a group of disorders exclusive to sleep and wake to sleep transition that encompass arousal with abnormal motor, behavioural or sensory experiences.

Types of Parasomnias

disorders from NREM
1.confusonal arousal
2. sleep waking
3. sleep terror
4.NFLE

disorders from REM
1. REM sleep behaviuor disorders
2. sleep paralysis
3.nightmare disorders

other parasomnias
1. sleep enuresis
2. sleep related groaning
3. sleep related eating disorders
4. exploding head syndrome
5. sleep related dissociative disorders

Diagnosis

Based on history, video EEG, PSG

Management

counceling and support
sleep hygine
Medications- BZD, SSRI, melatonin
behavior therapy, relaxation therapy etc